Second‐Generation Tris(2‐pyridylmethyl)amine–Zinc Complexes as Probes for Enantiomeric Excess Determination of Amino Acids. Issue 11 (21st March 2017)

• Record Type: Journal Article
• Authors: Scaramuzzo, Francesca A.; Badetti, Elena; Licini, Giulia; Zonta, Cristiano
• Is Part Of: European journal of organic chemistry. Issue 11(2017)
• Page Start: 1438
• Page End: 1442
• Publication Date: 2017-03-21
• Subjects: Tripodal ligands -- N ligands -- Circular dichroism -- Zinc -- Chirality; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201601381
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Self‐assembly through imine condensation chemistry in combination with metal coordination is becoming one of the leading strategies for the preparation of stereodynamic probes for the determination of enantiomeric excess. Recently, we reported a novel molecular architecture based on a modified tris(2‐pyridylmethyl)amine–zinc(II) complex [TPMA = tris(2‐pyridylmethyl)amine] that is able to function as an optical probe for the determination of the enantiomeric excess of amino acids. Herein, we report on how a slight modification of the TPMA ligand enhances both the dichroic response and the stability of the system. The novel probe provides a much higher dichroic signal compared with the previously reported system. Abstract : A novel probe based on the TPMA ligand upon reaction with amino acids shows an enhanced dichroic response compared with the previously reported systems due to a different spatial arrangement.