Cover Picture: Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates (ChemMedChem 7/2017). (6th April 2017)

• Record Type: Journal Article
• Authors: Sirvent, Juan Alberto; Lücking, Ulrich
• Is Part Of: ChemMedChem. Volume 12:Number 7(2017)
• Page Start: 476
• Page End: 476
• Publication Date: 2017-04-06
• Subjects: drug design -- kinase inhibitors -- medicinal chemistry -- pharmacophores -- sulfoximines; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201700179
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The front cover picture shows the general structure of a sulfoximine group in front of a charge density distribution from a computational modeling study, surrounded by a puzzle of tablets that is still being assembled. Sulfoximines, the monoaza‐analogues of sulfones, have been neglected in the life sciences for a long time but have gained considerable recognition as a new and versatile structural motif just recently. The synthetic methodology for sulfoximines has progressed significantly; however, the general understanding of this functional group regarding the medicinal‐chemistry‐relevant properties is still limited. To contribute novel pieces to the emerging picture of sulfoximines in drug discovery, researchers at Bayer AG prepared a set of direct sulfoximine analogues of marketed drugs and advanced clinical candidates to compare the in vitro properties of the matched molecular pairs with respect to biological activity, pharmacokinetics, and physicochemistry. More information can be found in the Full Paper by Ulrich Lücking and Juan Alberto Sirvent onpage 487 in Issue 7, 2017 (DOI:10.1002/cmdc.201700044 ).