Bioactive sesquiterpenes from an endophytic fungus Bipolaris sorokiniana isolated from a popular medicinal plant Costus speciosus. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Qader, M. Mallique; Kumar, N. Savitri; Jayasinghe, Lalith; Araya, Hiroshi; Fujimoto, Yoshinori
• Is Part Of: Mycology. Volume 8:Issue 1(2017)
• Page Start: 17
• Page End: 20
• Publication Date: 2017-01-02
• Subjects: Endophytic fungus -- Bipolaris sorokiniana -- Costus speciosus -- Helminthosporal acid -- helminthosporol; Fungi -- Periodicals; Mycology -- Periodicals; Fungi; Mycology; Periodicals; 579.505
• DOI: 10.1080/21501203.2016.1269844
• Languages: English
• ISSNs: 2150-1203

Abstract

ABSTRACT: Bipolaris sorokiniana, a fungal endophyte, was isolated from the leaves of Costus speciosus, a popular medicinal plant used to control diabetes. Fermentation of the fungus in potato dextrose broth and chromatographic purification of the ethyl acetate (EtOAc) extracts of the culture broth and mycelium yielded two rare sesquiterpenes helminthosporal acid (1 ) and helminthosporol (2 ), together with ergosterol. Compounds1 and2 showed a strong phytotoxic effect on lettuce seed germination and toxicity against brine shrimps. Compound1 also showed antifungal activity. Complete assignments of 1 H and 13 C NMR data of compound1 are described for the first time.