Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S. (2nd January 2017)

• Record Type: Journal Article
• Authors: Holsten, Till; Schuster, Tobias; Grabhorn, Enke; Hero, Barbara; Frühwald, Michael C.
• Is Part Of: Pediatric hematology and oncology. Volume 34:Number 1(2017)
• Page Start: 17
• Page End: 23
• Publication Date: 2017-01-02
• Subjects: HACE -- liver transplantation -- neuroblastoma -- stage 4S; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Hematologic Diseases -- Child; Hematologic Diseases -- Infant; Neoplasms -- Child; 618.9215
• DOI: 10.1080/08880018.2016.1266535
• Languages: English
• ISSNs: 0888-0018

Abstract

ABSTRACT: Neuroblastoma (NBL) stage 4s is an incompletely understood phenomenon with variable clinical course. While the majority of patients may undergo spontaneous regression and achieve complete resolution without intensive therapy, a small proportion is at increased risk of developing secondary complications. One such situation is liver insufficiency due to diffuse metastases. We report a patient suffering from NBL 4S who required double lifesaving liver transplantation. Abdominal and respiratory complications due to hepatomegaly are crucial determinants for treatment intensity and duration in 4S NBL[1, 2] . We provide an algorithm in order to facilitate the clinical decision when dealing with similar potentially life-threatening events.