Cyclooxygenase-2 Induction by Amino Acid Deprivation Requires p38 Mitogen-Activated Protein Kinase in Human Glioma Cells. (21st April 2017)

• Record Type: Journal Article
• Authors: Li, Zhiwen; Chang, Chi-Ming; Wang, Lanfang; Zhang, Ping; Shu, Hui-Kuo G.
• Is Part Of: Cancer investigation. Volume 35:Number 4(2017)
• Page Start: 237
• Page End: 247
• Publication Date: 2017-04-21
• Subjects: Glioblastomas -- amino acid deprivation -- COX-2 -- p38-MAPK -- VEGF; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2017.1292517
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: Glioblastomas (GBMs) are malignant brain tumors that can outstrip nutrient supplies due to rapid growth. Cyclooxygenase-2 (COX-2) has been linked to GBMs and may contribute to their aggressive phenotypes. Amino acid starvation results in COX-2 mRNA and protein induction in multiple human glioma cell lines in a process requiring p38 mitogen-activated protein kinase (p38-MAPK) and the Sp1 transcription factor. Increased vascular endothelial growth factor expression results from starvation-dependent COX-2 induction. These data suggest that COX-2 induction with amino acid deprivation may be a part of the adaptation of glioma cells to these conditions, and potentially alter cellular response to anti-neoplastic therapy.