Hepatoprotective hemiterpene glycosides from the rhizome of Cibotium barometz (L.) J. Sm. (June 2017)

• Record Type: Journal Article
• Authors: Xie, Mei-Ping; Li, Lan; Sun, Hua; Lu, An-Qi; Zhang, Bo; Shi, Jian-Gong; Zhang, Dan; Wang, Su-Juan
• Is Part Of: Phytochemistry. Volume 138(2017)
• Page Start: 128
• Page End: 133
• Publication Date: 2017-06
• Subjects: Cibotium barometz (L.) J. Sm. -- Dicksoniaceae -- Hemiterpene glycosides -- Hepatoprotection; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.02.023
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Five previously undescribed hemiterpene glycosides, cibotiumbarosides E−I, and two known hemiterpene glucosides, were isolated from the rhizome of Cibotium barometz (L.) J. Sm. The structures of cibotiumbarosides E−I were established by 1D and 2D NMR spectroscopic analyses and HRMS. The absolute configuration of the aglycone of cibotiumbaroside E was assigned by calculated ECD with the TDDFT method. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activity against APAP-induced acute liver damage in vitro, which were more effective than the positive control, bicyclol. On the other hand, seven hemiterpene glycosides were all inactive in assays of cytotoxicity, neuroprotection, antidiabetes and anti-inflammation. Graphical abstract: Five previously undescribed hemiterpene glycosides, cibotiumbarosides E−I, along with two known were isolated from the rhizome of Cibotium barometz (L.) J. Sm. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activity against APAP-induced acute liver damage in vitro, which is more effective than the positive control, bicyclol. Highlights: Five previously undescribed hemiterpene glycosides were isolated from the rhizome of Cibotium barometz (L.) J. Sm. The structures of cibotiumbarosides E−I were established by NMR. The absolute configuration was assigned by calculated ECD. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activities, more effective than bicyclol.