Assembly of a β-(1 → 3)-glucan laminarihexaose on ionic liquid support. Issue 16 (19th April 2017)

• Record Type: Journal Article
• Authors: Wang, Yanhui; Zhao, Xiaoke; Kong, Qiuyun; Yao, Jiajian; Meng, Xiangbao; Li, Zhongjun
• Is Part Of: Tetrahedron letters. Volume 58:Issue 16(2017)
• Page Start: 1655
• Page End: 1658
• Publication Date: 2017-04-19
• Subjects: Ionic liquid -- Beta glucans -- Laminarihexaose -- Oligosaccharide -- Rapid assembly; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.03.035
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: β-(1 → 3)-d -Glucan on ionic liquid (IL)-support was prepared with no chromatography required. IL-support laminarihexaose was rapidly assembled in 15 h with an average yield of over 90% per step. Combination of glycosylating agents were optimized by promoter, solvent, temperature. Abstract: An efficient method for the preparation of β-(1 → 3)-d -glucan laminarihexaose on ionic liquid (IL)-support is described. A β-(1 → 3)-glucan laminarihexaose was rapidly assembled in 15 h in a stereoselective fashion with an average yield of over 90% per step using an optimized combination of glycosylating agents. This ionic liquid support approach provides an efficient and fast means for the assembly of β-(1 → 3)-glucans.