Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Issue 18 (4th May 2017)

• Record Type: Journal Article
• Authors: Sonnenschein, Eva C.; Stierhof, Marc; Goralczyk, Stephan; Vabre, Floriane M.; Pellissier, Leonie; Hanssen, Kine Østnes; de la Cruz, Mercedes; Díaz, Caridad; de Witte, Peter; Copmans, Daniëlle; Andersen, Jeanette Hammer; Hansen, Espen; Kristoffersen, Venke; Tormo, José R.; Ebel, Rainer; Milne, Bruce F.; Deng, Hai; Gram, Lone; Jaspars, Marcel; Tabudravu, Jioji N.
• Is Part Of: Tetrahedron. Volume 73:Issue 18(2017)
• Page Start: 2633
• Page End: 2637
• Publication Date: 2017-05-04
• Subjects: Pseudoalteromonas -- Siderophore -- Pseudochelin A -- NMR -- LCMS; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.03.051
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A new siderophore containing a 4, 5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa . Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity. Graphical abstract: