Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2·2H2O/4, 7-diphenyl-1, 10-phenanthroline. Issue 16 (19th April 2017)

• Record Type: Journal Article
• Authors: Liu, Xiao-Dong; Ma, Hai-Yan; Xing, Chun-Hui; Lu, Long
• Is Part Of: Tetrahedron letters. Volume 58:Issue 16(2017)
• Page Start: 1564
• Page End: 1567
• Publication Date: 2017-04-19
• Subjects: Trifluoromethyl ketone -- Alkynylation -- Propargyl alcohol -- Copper fluride; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.03.010
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Mild reaction conditions, convenient manipulation. Moisture tolerance. Wide substrates scope. Abstract: CuF2 ·2H2 O/4, 7-diphenyl-1, 10-phenanthroline was found to be a highly efficient catalyst for the nucleophilic alkynylation of cyclopropyl trifluoromethyl ketone. The corresponding trifluoromethyl-substituted tertiary propargyl alcohols were synthesized in moderate to excellent yields under mild conditions. The catalyst system could also be applied to aromatic trifluoromethyl ketone as well as trifluoropyruvate.