Synthesis and biological evaluation of fentanyl acrylic derivatives. Issue 32 (5th April 2017)
- Record Type:
- Journal Article
- Title:
- Synthesis and biological evaluation of fentanyl acrylic derivatives. Issue 32 (5th April 2017)
- Main Title:
- Synthesis and biological evaluation of fentanyl acrylic derivatives
- Authors:
- Li, Shaohua
Cohen-Karni, Devora
Kovaliov, Marina
Tomycz, Nestor
Cheng, Boyle
Whiting, Donald
Averick, Saadyah - Abstract:
- Abstract : Synthesis and biological evaluation of fentanyl acrylic derivatives. Abstract : The synthesis of novel fentanyl acrylate derivatives via bromo-fentanyl using Heck coupling is described. The synthesis is concise and represents an efficient and useful method for functionalizing fentanyl for medicinal chemistry investigations. The agonistic and analgesic activities are evaluated by Mu opioid receptor activation and hot plate assays in mice.
- Is Part Of:
- RSC advances. Volume 7:Issue 32(2017)
- Journal:
- RSC advances
- Issue:
- Volume 7:Issue 32(2017)
- Issue Display:
- Volume 7, Issue 32 (2017)
- Year:
- 2017
- Volume:
- 7
- Issue:
- 32
- Issue Sort Value:
- 2017-0007-0032-0000
- Page Start:
- 20015
- Page End:
- 20019
- Publication Date:
- 2017-04-05
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c7ra01346a ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 91.xml