A dual removable activating group enabled the Povarov reaction of N-arylalanine esters: synthesis of quinoline-4-carboxylate esters. Issue 14 (14th March 2017)

• Record Type: Journal Article
• Authors: Jia, Xiaodong; Lü, Shiwei; Yuan, Yu; Zhang, Xuewen; Zhang, Liang; Luo, Liangliang
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 14(2017)
• Page Start: 2931
• Page End: 2937
• Publication Date: 2017-03-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00446j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A dual removable activating group enabled Povarov reaction of N -arylalanine esters was reported. Abstract : A dual removable activating group enabled Povarov reaction of N -arylalanine esters was reported. N -Arylalanine ester was utilized as the sole carbon source to generate N -arylimine and its tautomer, enamine, in situ by aerobic oxidation of sp 3 C–H bonds, and then the consecutive reaction delivered the desired quinoline-4-carboxylate esters in high yields.