A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography. Issue 3 (4th November 2016)

• Record Type: Journal Article
• Authors: Ko, Zhen Yu Gordon; Mehta, Kalpesh; Jamil, Muhammad; Yap, Choon Hwai; Chen, Nanguang
• Is Part Of: Journal of biophotonics. Volume 10:Issue 3(2017)
• Page Start: 353
• Page End: 359
• Publication Date: 2016-11-04
• Subjects: optical coherence tomography -- image reconstruction technique -- medical and biological imaging; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201600119
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : Congenital cardiovascular defects are the leading cause of birth defect related death. It has been hypothesized that fluid mechanical forces of embryonic blood flow affect cardiovascular development and play a role in congenital malformations. Studies in small animal embryos can improve our understanding of congenital malformations and can lead to better treatment. We present a feasibility study in which high‐resolution optical coherence tomography (OCT) and computational fluid dynamics (CFD) are combined to provide quantitative analysis of the embryonic flow mechanics and the associated anatomy in a small animal model.