One-pot synthesis of injectable methylcellulose hydrogel containing calcium phosphate nanoparticles. (10th February 2017)

• Record Type: Journal Article
• Authors: Park, Hanna; Kim, Min Hee; Yoon, Young Il; Park, Won Ho
• Is Part Of: Carbohydrate polymers. Volume 157(2017)
• Page Start: 775
• Page End: 783
• Publication Date: 2017-02-10
• Subjects: Methylcellulose -- Thermo-sensitive hydrogel -- Injectable gel -- Calcium phosphate nanoparticles -- In situ formation; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.10.055
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Thermo-sensitive nethylcellulose hydrogel containing CaP nanoparticles was synthesized by one-pot reaction. Precursor salts for CaP nanoparticles accelerate hydrogelation of methylcellulose. Injectable methylcellulose hydrogel with CaP nanoparticles has a great potential for bone regeneration. Abstract: A thermo-sensitive hydrogel based on calcium phosphate nanoparticles was prepared using a novel one-pot method in which added precursor salts induced a salt-out effect in the methylcellulose (MC) solution. The calcium phosphate nanoparticles were synthesized in situ from precursor ions (Ca 2+ and HPO4 2− ) in the hydrogel, and residual ions (HPO4 2− and Cl − ) in the formation of the nanoparticles decreased the gelation temperature of the MC solution. This one-pot synthesis was an effective way to streamline the previous multi-step process and to easily prepare a thermo-sensitive hydrogel containing bioactive nanoparticles. The thermo-sensitive properties of different concentrations of MC hydrogels were characterized by a rheometer and infrared (IR) spectroscopy. The gelation behavior of MC according to the addition of various salts was monitored by rheometer. With respect to a selected concentration and precursor, the structure of the MC hydrogel containing calcium phosphate nanoparticles was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and IR.