Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. (10th February 2017)

• Record Type: Journal Article
• Authors: Xu, Nuo; Gao, Zheng; Zhang, Jianjun; Jing, Huijuan; Li, Shangshang; Ren, Zhenzhen; Wang, Shouxian; Jia, Le
• Is Part Of: Carbohydrate polymers. Volume 157(2017)
• Page Start: 196
• Page End: 206
• Publication Date: 2017-02-10
• Subjects: ALP Alkaline phosphatase -- ALT Alamine aminotransferase -- Ara Arabinose -- AST Aspertate aminotransferase -- CAT Catalase -- En-MPS Enzymatic- extractable polysaccharides -- En-MZPS Enzymatic- extractable zinc polysaccharides -- Gal galactose -- GC Gas chromatography -- Glu Glucose -- GSH-Px GSH peroxide -- HDL-C High-density lipoprotein cholesterol -- HFHCM High-fat-high-cholesterol emulsion -- LDL-C Low density lipoprotein cholesterol -- LPO Lipid peroxidation -- Man Mannose -- MC Model control -- MDA Malondialdehyde -- NC Normal control -- O-2 Superoxide anion -- PC Positive control -- prot Protein -- Rha Rhamnose -- Rib Ribose -- ROS Reactive oxygen species -- SOD Superoxide dismutase -- Xyl Xylose -- T-AOC Total antioxidant capacity -- TC Total cholesterol -- TG Triglyceride -- VLDL-C Very low-density lipoprotein cholesterol; Hepatoprotective effects -- Enzymatic-extractable -- Mycelia zinc polysaccharides -- Pleurotus eryngii var. tuoliensis; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.09.082
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The mycelia zinc polysaccharide by Pleurotus eryngii var. tuoliensis was isolated. Hyperlipidemic mice were established by high-fat-high-cholesterol emulsion. The hepatoprotective effects of En-MZPS were investigated. The glucose was determined to the major monosaccharide component of En-MZPS. Findings demonstrated that En-MZPS had potential prevention of hyperlipidemia. Abstract: The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM). The results showed that the supplementation of En-MZPS had potential anti-hyperlipidemia effects on reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT and AST) and serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), enhancing the antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), and decreasing the lipid peroxidation (MDA and LPO). Furthermore, the in vitro scavenging results indicated that the inhibition effects of En-MZPS on hydroxyl radicals and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals reached 59.98 ± 6.29% and 37.01 ± 2.15%, respectively. These conclusions demonstrated that the En-MZPS might be suitable for functional foods and natural drugs in preventing the HFHCM-induced hyperlipidemia and non-alcoholic fatty liver.