Catalytic asymmetric Meerwein–Ponndorf–Verley reduction of glyoxylates induced by a chiral N, N′-dioxide/Y(OTf)3 complex. Issue 22 (3rd March 2017)

• Record Type: Journal Article
• Authors: Wu, Wangbin; Zou, Sijia; Lin, Lili; Ji, Jie; Zhang, Yuheng; Ma, Baiwei; Liu, Xiaohua; Feng, Xiaoming
• Is Part Of: Chemical communications. Volume 53:Issue 22(2017)
• Page Start: 3232
• Page End: 3235
• Publication Date: 2017-03-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc00273d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An asymmetric MPV reduction of glyoxylates was for the first time achieved with excellent results and the mechanism of the reaction was probed. Abstract : An asymmetric Meerwein–Ponndorf–Verley (MPV) reduction of glyoxylates was for the first time accomplished via an N, N ′-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves (MSs) as crucial additives. A variety of optically active α-hydroxyesters were obtained with excellent results. A possible reaction mechanism was proposed based on the experiments.