Facile synthesis of polypyrrole@metal–organic framework core–shell nanocomposites for dual-mode imaging and synergistic chemo-photothermal therapy of cancer cells. Issue 9 (15th February 2017)

• Record Type: Journal Article
• Authors: Chen, Xiangjun; Zhang, Manjie; Li, Shengnan; Li, Lu; Zhang, Lingyu; Wang, Tingting; Yu, Min; Mou, Zhongcheng; Wang, Chungang
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 9(2017)
• Page Start: 1772
• Page End: 1778
• Publication Date: 2017-02-15
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb03218d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A facile route was developed to fabricate PPy@MOF for dual-mode magnetic resonance/photoacoustic imaging and synergistic chemo-photothermal therapy. Abstract : In our work, we report a facile approach to fabricate well-dispersed polypyrrole@metal–organic framework (PPy@MOF) core–shell nanocomposites (NCs) with a polypyrrole (PPy) core and an MIL-100(Fe) shell. The adsorbed Fe(iii ) ions on the as-fabricated PPy surface were utilized as reactive sites for further growth of the MIL-100(Fe) in the presence of trimesic acid (H3 btc). The resulting NCs exhibited strong absorption in the near infrared (NIR) region and possessed an excellent photothermal efficiency of ∼40% resulting from the PPy core. The MOF structure based on Fe(iii ) carboxylate materials held great ability for storage/delivery of the hydrophilic anti-cancer drug, doxorubicin (DOX). The released DOX continuously increased due to the damage of the shell at low pH values. When the DOX-loaded PPy@MIL-100(Fe) NCs were exposed to NIR irradiation, owing to the heat produced by the NCs, the local temperature increased, resulting in a faster release of DOX from the MIL-100(Fe) shell. Furthermore, PPy@MIL-100(Fe) NCs were successfully employed for dual-mode magnetic resonance imaging (MRI)/photoacoustic imaging (PAI) and synergistic chemo-photothermal therapy of cancer cells. Therefore, our work could encourage further study in the construction of a multifunctional platform using different MOF nanomaterials for cancer theranostics.