Incorporating isosorbide as the chain extender improves mechanical properties of linear biodegradable polyurethanes as potential bone regeneration materials. Issue 23 (1st March 2017)

• Record Type: Journal Article
• Authors: Ma, Yufei; Liu, Juan; Luo, Min; Xing, Juan; Wu, Jinchuan; Pan, Haobo; Ruan, Changshun; Luo, Yanfeng
• Is Part Of: RSC advances. Volume 7:Issue 23(2017)
• Page Start: 13886
• Page End: 13895
• Publication Date: 2017-03-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra28826j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Novel linear biodegradable polyurethanes based on poly (d, l -lactic acid) as soft segments and isosorbide as chain extender were exhibited with high molecular weight and appropriate mechanical performances, promising as the scaffold materials for bone regeneration. Abstract : One key limitation to the application of linear biodegradable polyurethanes (LBPUs) in scaffold materials for bone regeneration is their insufficient mechanical properties. In this study, isosorbide (ISO), a rigid two-ring small diol is selected as a chain extender to produce a series of new poly (d, l -lactide)-based polyurethanes (ISO-PUs). It is confirmed that incorporating ISO as the chain extender can significantly reduce the crosslinking degree of ISO-PUs and thus increase their molecular weight and mechanical properties. ISO-PUs with M n values of 72.09 kDa and 84.79 kDa demonstrate higher tensile strength & modulus (39.87 MPa & 2.19 GPa and 42.68 MPa & 2.57 GPa) than PDLLA with a M n of 100 kDa (36.15 MPa & 2.07 GPa). All these results, together with the sound cytocompatibility of ISO-PUs with MC3T3-E1 cells based on the morphology observation and cell proliferation, suggest that ISO-PU should be a promising scaffold material for bone regeneration.