Diametral compression behavior of biomedical titanium scaffolds with open, interconnected pores prepared with the space holder method. (April 2017)

• Record Type: Journal Article
• Authors: Arifvianto, B.; Leeflang, M.A.; Zhou, J.
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 68(2017)
• Page Start: 144
• Page End: 154
• Publication Date: 2017-04
• Subjects: Titanium scaffold -- Porous structure -- Micro-CT -- Permeability -- diametral compression test -- Mechanical properties; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2017.01.046
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Scaffolds with open, interconnected pores and appropriate mechanical properties are required to provide mechanical support and to guide the formation and development of new tissue in bone tissue engineering. Since the mechanical properties of the scaffold tend to decrease with increasing porosity, a balance must be sought in order to meet these two conflicting requirements. In this research, open, interconnected pores and mechanical properties of biomedical titanium scaffolds prepared by using the space holder method were characterized. Micro-computed tomography (micro-CT) and permeability analysis were carried out to quantify the porous structures and ascertain the presence of open, interconnected pores in the scaffolds fabricated. Diametral compression (DC) tests were performed to generate stress-strain diagrams that could be used to determine the elastic moduli and yield strengths of the scaffolds. Deformation and failure mechanisms involved in the DC tests of the titanium scaffolds were examined. The results of micro-CT and permeability analyses confirmed the presence of open, interconnected pores in the titanium scaffolds with porosity over a range of 31–61%. Among these scaffolds, a maximum specific surface area could be achieved in the scaffold with a total porosity of 5–55%. DC tests showed that the titanium scaffolds with elastic moduli and yield strengths of 0.64–3.47 GPa and 28.67–80 MPa, respectively, could be achieved. By comprehensive consideration of specific surface area, permeability and mechanical properties, the titanium scaffolds with porosities in a range of 50−55% were recommended to be used in cancellous bone tissue engineering. Graphical abstract: Highlights: Diametral compression (DC) test was used to characterize titanium (Ti) scaffolds. The space holder method could produce titanium scaffolds with interconnected pores. The DC test could be used to determine mechanical properties of titanium scaffold. Porous Ti with ~50% porosity was suitable as a scaffold for cancellous bone.