Analgesic and anti-inflammatory activities of 80% methanol root extract of Jasminum abyssinicum Hochst. ex. Dc. (Oleaceae) in mice. (18th April 2017)

• Record Type: Journal Article
• Authors: Tadiwos, Yohannes; Nedi, Teshome; Engidawork, Ephrem
• Is Part Of: Journal of ethnopharmacology. Volume 202(2017)
• Page Start: 281
• Page End: 289
• Publication Date: 2017-04-18
• Subjects: J. abyssinicum -- Anti-inflammatory -- Analgesia; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2017.02.036
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Background: Pain and inflammation are associated with the pathophysiology of various clinical conditions. Most analgesic and anti-inflammatory drugs available in the market present a wide range of problems. The current study was aimed at investigating the analgesic and anti-inflammatory activity of 80% methanol extract of J. abyssinicum root. Methods: The analgesic activity was determined using tail-flick test and acetic acid induced writhing, whereas anti-inflammatory activity was determined by carrageenan induced paw edema and formalin induced pedal edema, carried out in vivo. The test group received three different doses of the extract (50 mg/kg, 100 mg/kg and 200 mg/kg) orally. The positive control group received diclofenac (10 mg/kg), aspirin (100 mg/kg or 150 mg/kg) or morphine (20 mg/kg) orally. The negative control group received vehicle (2% Tween 80, 10 ml/kg) orally. Furthermore, preliminary phytochemical screening was carried out. Results: Oral administration of J. abbysinicum 80% methanol extract (at all doses) significantly (p<0.001) inhibit pain sensation in the pain models. Similarly, the extract demonstrated anti-inflammatory effect in the inflammation models in mice. Preliminary phytochemical screening showed the presence of saponins, flavonoids, terpenoids, triterpenens and glycosides. Conclusion: The data obtained from the present study indicates that the extract possessed a significant analgesic and anti-inflammatory activity, upholding the folkloric use of the plant.