Predicting epileptic seizures from scalp EEG based on attractor state analysis. (May 2017)

• Record Type: Journal Article
• Authors: Chu, Hyunho; Chung, Chun Kee; Jeong, Woorim; Cho, Kwang-Hyun
• Is Part Of: Computer methods and programs in biomedicine. Volume 143(2017)
• Page Start: 75
• Page End: 87
• Publication Date: 2017-05
• Subjects: Electroencephalography (EEG) -- Epileptic seizure -- Early-warning indicator -- Attractor state -- Spectral feature -- prediction -- Systems biology; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2017.03.002
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: The seizure-precursor phenomenon of the epileptic seizure is extracted from an attractor-based analysis of the macroscopic dynamics of the brain. A novel seizure prediction method using scalp electroencephalogram (EEG) based on attractor state analysis is proposed. High sensitivity of 86.67% with a false prediction rate of 0.367 per hour is achieved. Abstract: Background and Objective: Epilepsy is the second most common disease of the brain. Epilepsy makes it difficult for patients to live a normal life because it is difficult to predict when seizures will occur. In this regard, if seizures could be predicted a reasonable period of time before their occurrence, epilepsy patients could take precautions against them and improve their safety and quality of life. In this paper, we investigate a novel seizure precursor based on attractor state analysis for seizure prediction. Methods: We analyze the transition process from normal to seizure attractor state and investigate a precursor phenomenon seen before reaching the seizure attractor state. From the result of an analysis, we define a quantified spectral measure in scalp EEG for seizure prediction. From scalp EEG recordings, the Fourier coefficients of six EEG frequency bands are extracted, and the defined spectral measure is computed based on the coefficients for each half-overlapped 20-second-long window. The computed spectral measure is applied to seizure prediction using a low-complexity methodology. Results: Within scalp EEG, we identified an early-warning indicator before an epileptic seizure occurs. Getting closer to the bifurcation point that triggers the transition from normal to seizure state, the power spectral density of low frequency bands of the perturbation of an attractor in the EEG, showed a relative increase. A low-complexity seizure prediction algorithm using this feature was evaluated, using ∼583 h of scalp EEG in which 143 seizures in 16 patients were recorded. With the test dataset, the proposed method showed high sensitivity (86.67%) with a false prediction rate of 0.367 h −1 and average prediction time of 45.3 min. Conclusions: A novel seizure prediction method using scalp EEG, based on attractor state analysis, shows potential for application with real epilepsy patients. This is the first study in which the seizure-precursor phenomenon of an epileptic seizure is investigated based on attractor-based analysis of the macroscopic dynamics of the brain. With the scalp EEG, we first propose use of a spectral feature identified for seizure prediction, in which the dynamics of an attractor are excluded, and only the perturbation dynamics from the attractor are considered.