Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus). (July 2017)

• Record Type: Journal Article
• Authors: Jondreville, Catherine; Cariou, Ronan; Méda, Bertrand; Dominguez-Romero, Elena; Omer, Elsa; Dervilly-Pinel, Gaud; Le Bizec, Bruno; Travel, Angélique; Baéza, Elisabeth
• Is Part Of: Chemosphere. Volume 178(2017)
• Page Start: 424
• Page End: 431
• Publication Date: 2017-07
• Subjects: Animal-derived food -- Brominated flame retardant -- Lipophilic contaminant -- Half-life -- Elimination; AE assimilation efficiency -- AR accumulation ratio -- BW body weight -- FE feed efficiency -- FI feed intake -- HBCDD hexabromocyclododecane; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2017.03.064
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in fast-growing (FG) and slow-growing (SG) broilers, through an exposure to a dietary concentration of 50 ng α-HBCDD g −1 feed during 42 and 84 days, respectively. Depuration parameters were assessed in SG broilers successively exposed during 42 days and depurated during 42 days. At market age, SG broilers had ingested 42% more feed than FG broilers, while their body weight gain per g of feed ingested was 34% lower. No isomerization of α- to β- or γ-HBCDD forms occurred, while OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the strain, abdominal fat displayed the highest α-HBCDD concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of α-HBCDD were slightly higher in SG (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in FG broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in SG broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50%. The overall assimilation efficiency of α-HBCDD was estimated at 58 and 50% in FG and SG broilers, respectively, while 22 and 17% of α-HBCDD ingested were estimated to be eliminated in excreta as metabolites. Highlights: A kinetic study of α-HBCDD was conducted in fast- and slow-growing broilers. α-HBCDD preferentially accumulated in fatty tissues. α-HBCDD was more concentrated in lipids of leg muscles than of breast muscle. Muscles were slightly more concentrated in slow- than in fast-growing broilers. Depuration half-life was 12–20 d, of which 50% due to dilution through growth.