Novel 11-norbetaenone isolated from an entomopathogenic fungus Lecanicillium antillanum. Issue 9 (1st May 2017)

• Record Type: Journal Article
• Authors: Li, Chi-Ying; Lo, I-Wen; Wang, Shih-Wei; Hwang, Tsong-Long; Chung, Yu-Ming; Cheng, Yuan-Bin; Tseng, Sung-Pin; Liu, Yi-Hung; Hsu, Yu-Ming; Chen, Shu-Rong; Hu, Hao-Chun; Chang, Fang-Rong; Wu, Yang-Chang
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 9(2017)
• Page Start: 1978
• Page End: 1982
• Publication Date: 2017-05-01
• Subjects: Lecanicillium antillanum -- Betaenone -- Secondary metabolite -- Polyketide synthase -- Anti-angiogenic effect; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.03.019
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A novel nor-betaenone compound, 11-norbetaenone (1 ), was isolated from the culture broth of an entomopathogenic fungus Lecanicillium antillanum . The structure was determined on the basis of 1D and 2D NMR spectroscopic data. The absolute stereochemistry of1 was further confirmed by X-ray single crystallography analysis. It is the first secondary metabolite reported from the species Lecanicillium antillanum . And it is also the first time that a betaenone-type compound was isolated from the genus Lecanicillium . Furthermore, 11-norbetaenone (1 ) displayed significant anti-angiogenic effect by suppressing tube formation.