Highly oxygenated antiausterity agents from the leaves of Uvaria dac. Issue 9 (1st May 2017)

• Record Type: Journal Article
• Authors: Awale, Suresh; Tawila, Ahmed M.; Dibwe, Dya Fita; Ueda, Jun-ya; Sun, Sijia; Athikomkulchai, Sirivan; Balachandran, Chandrashaker; Saiki, Ikuo; Matsumoto, Kinzo; Esumi, Hiroyasu
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 9(2017)
• Page Start: 1967
• Page End: 1971
• Publication Date: 2017-05-01
• Subjects: Uvaria dac -- Pancreatic cancer -- Antiausterity agents -- Preferential cytotoxicity -- PANC-1; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.03.021
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: From the chloroform extract of the leaves of Uvaria dac, four new highly-oxygenated cyclohexene derivatives named uvaridacols I–L (1 –4 ) were isolated together with nine previously reported compounds (5 –13 ). Their structures were determined based on the extensive NMR spectroscopic data and circular dichroism spectroscopic analysis. Among the new compounds, uvaridacol L (4 ) displayed strong preferential cytotoxicity in the nutrient deprived medium against five different tested pancreatic cancer cell lines, PANC-1 (PC50, 20.1 μM), PSN-1 (PC50, 9.7 μM), MIA PaCa-2 (PC50, 29.1 μM), Capan-1 (73.0 μM) and KLM-1 (25.9 μM).