Correlation between mucin biology and tumor heterogeneity in lung cancer. (April 2017)

• Record Type: Journal Article
• Authors: Xu, Menglin; Wang, Diane C.; Wang, Xiangdong; Zhang, Yong
• Is Part Of: Seminars in cell & developmental biology. Volume 64(2017)
• Page Start: 73
• Page End: 78
• Publication Date: 2017-04
• Subjects: MUC -- Tumor heterogeneity -- Lung cancer -- Diagnosis -- Therapy; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.08.027
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Mucins (MUC) are a family consisting of large O-glycoproteins whose primary functions are to protect and lubricate cell epithelial surfaces and contribute to intra- and inter-cellular signal pathways, cell proliferation, growth and apotosis. With the development of new technologies, MUCs begin to be identified as an effective marker in evaluating the tumor heterogeneity in lung cancer. MUCs' diverse expressions in subtypes of lung cancer indicate the inter-tumor heterogeneity. MUCs' mutation may also contribute to the development of intra-heterogeneity and evolution of lung cancer. Understanding MUCs' association with lung cancer heterogeneity and its molecular regulatory mechanism will benefit the development of diagnosis, therapy choice, and prognosis prediction of lung cancer.