Enhancement of the antiviral activity against caprine herpesvirus type 1 of Acyclovir in association with Mizoribine. (April 2017)

• Record Type: Journal Article
• Authors: Camero, Michele; Buonavoglia, Domenico; Lucente, Maria Stella; Losurdo, Michele; Crescenzo, Giuseppe; Trerotoli, Paolo; Casalino, Elisabetta; Martella, Vito; Elia, Gabriella; Tempesta, Maria
• Is Part Of: Research in veterinary science. Volume 111(2017)
• Page Start: 120
• Page End: 123
• Publication Date: 2017-04
• Subjects: Acyclovir -- Mizoribine -- Association -- Antiviral activity -- In vitro -- Caprine herpesvirus 1; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2017.02.012
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Caprine herpesvirus 1 (CpHV-1) infection in goats is responsible for genital lesions resembling the lesions induced by herpesvirus 2 in humans (HHV-2). The immunosuppressive drug Mizoribine (MIZ) is able to increase the antiviral activity of Acyclovir (ACV) against herpesvirus infections, raising interesting perspectives on new combined therapeutic strategies. In this study the anti-CpHV-1 activity in vitro of ACV alone or in combination with MIZ was evaluated. ACV (100 μg/ml) displayed an antiviral effect on CpHV-1 replication. This inhibitory effect was higher when ACV (100 μg/ml) was used in association with MIZ (20 μg/ml). Other combinations of ACV and MIZ in various concentrations were not as effective as ACV 100 μg/ml / MIZ 20 μg/ml. These findings suggest that the association of ACV and MIZ is potentially useful for treatment of genital infection by herpesviruses. Highlights: Caprine herpesvirus 1 (CpHV-1) infection in goats resembles genital human herpesvirus infection. The activity in vitro against CpHV-1 of acyclovir alone or in combination with mizoribine was evaluated. Acyclovir 100μg/ml inhibited CpHV-1 replication and the inhibition was higher when used with mizoribine 20μg/ml. The association acyclovir/mizoribine could be useful for treatment of herpesviral genital infection