What evolution tells us about protein physics, and protein physics tells us about evolution. (February 2017)

• Record Type: Journal Article
• Authors: Bastolla, Ugo; Dehouck, Yves; Echave, Julian
• Is Part Of: Current opinion in structural biology. Volume 42(2017)
• Page Start: 59
• Page End: 66
• Publication Date: 2017-02
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2016.10.020
• Languages: English
• ISSNs: 0959-440X

Abstract

Abstract : Highlights: Protein physics constraints evolution and evolution constraints protein physics. Selection targets protein stability to prevent aggregation and enhance function. Population size and mutation rates affect the physics of evolved proteins. Mutation rate, mutation bias and robustness are subject to natural selection. Selection amplifies epistasis, with an impact on structural and evolutionary modeling. Abstract : The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.