Paradoxical response with increased tumor necrosis factor-α levels to anti-tuberculosis treatment in a patient with disseminated tuberculosis. (2017)

• Record Type: Journal Article
• Authors: Watanabe, Sho; Kaneko, Yugo; Kawamoto, Hironori; Maehara, Tomoki; Baba, Yuri; Fujisaki, Ikumi; Saito, Nayuta; Ryu, Kai; Seki, Aya; Horikiri, Tsugumi; Kinoshita, Akira; Takeda, Hiroshi; Saito, Keisuke; Kuwano, Kazuyosi
• Is Part Of: Respiratory medicine case reports. Volume 20(2017)
• Page Start: 201
• Page End: 204
• Publication Date: 2017
• Subjects: Adalimumab -- Immune reconstitution inflammatory syndrome -- Paradoxical response -- Tuberculosis -- Tumor necrosis factor alpha -- TNF-α inhibitor; ELISA enzyme-linked immunosorbent assay -- HRCT high resolution computer tomography -- IGRA Interferon gamma release assay -- IRIS immune reconstruction syndrome -- PR Paradoxical response -- TB tuberculosis -- TNFα Tumor necrosis factor alpha; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2017.02.011
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: It has been reported that tuberculosis (TB) worsens after cessation of tumor necrosis factor-α inhibitors and starting anti-TB treatment. Little is known about the immunological pathogenesis of this paradoxical response (PR). We report the first case of a TB patient in whom PR occurred concurrently with elevation of circulating tumor necrosis factor-α (TNFα) levels. A 75-year-old woman, who had been treated with adalimumab for SAPHO syndrome, developed disseminated TB. Soon after administration of anti-TB treatment (isoniazid, rifampicin, pyrazinamide, and ethambutol), and after discontinuation of adalimumab, a PR occurred. Serial testing of serum cytokine levels revealed a marked increase in TNFα, and a decline in interferon-γ levels. Despite intensive treatment with antibiotics, prednisolone, noradrenaline, and mechanical ventilation, acute respiratory distress syndrome developed and she died. Thus, overproduction of TNFα after cessation of TNFα inhibitors may partially account for the pathogenesis of a PR. This supports preventative or therapeutic reinitiation of TNFα inhibitors when PR occurs. Serial monitoring of circulating inflammatory cytokine levels could lead to earlier identification of a PR.