Neural correlates of graphic cigarette warning labels predict smoking cessation relapse. (30th April 2017)

• Record Type: Journal Article
• Authors: Owens, Max M.; MacKillop, James; Gray, Joshua C.; Hawkshead, Brittany E.; Murphy, Cara M.; Sweet, Lawrence H.
• Is Part Of: Psychiatry research. Volume 262(2017)
• Page Start: 63
• Page End: 70
• Publication Date: 2017-04-30
• Subjects: Nicotine dependence -- Warning labels -- Functional magnetic resonance imaging -- Relapse -- Smoking cessation -- Medial prefrontal cortex; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2017.02.005
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Exposure to graphic warning labels (GWLs) on cigarette packaging has been found to produce heightened activity in brain regions central to emotional processing and higher-order cognitive processes. The current study extends this literature by using functional magnetic resonance imaging (fMRI) to investigate neural activation in response to GWLs and use it to predict relapse in an evidence-based smoking cessation treatment program. Participants were 48 treatment-seeking nicotine-dependent smokers who completed an fMRI paradigm in which they were exposed to GWLs, text-only warning labels (TOLs), and matched control stimuli. Subsequently, they enrolled in smoking cessation treatment and their smoking behavior was monitored. Activation in bilateral amygdala, right dorsolateral prefrontal cortex, right inferior frontal gyrus, left medial temporal gyrus, bilateral occipital lobe, and bilateral fusiform gyrus was greater during GWLs than TOLs. Neural response in the ventromedial prefrontal cortex (vmPFC) during exposure to GWLs (relative to a visual control image) predicted relapse during treatment beyond baseline demographic and dependence severity, but response in the amygdala to GWLs did not. These findings suggest that neurocognitive processes in the vmPFC may be critical to understanding how GWL's induce behavior change and may be useful as a predictor of smoking cessation treatment prognosis. Highlights: "Graphic cigarette warnings activate several brain regions more than text warnings. Ventromedial prefrontal response to graphic warnings predicts cessation success. Specific processes are activated by graphic warnings that predict behavior change.