Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora. (March 2017)

• Record Type: Journal Article
• Authors: Tian, Dong-Song; Gu, Wei; Wang, Li-Ping; Huang, Lie-Jun; Rao, Qing; Huang, Tao; Fu, Yan-Hui; Zhang, Jian-Xin; Yuan, Chun-Mao; Hao, Xiao-Jiang
• Is Part Of: Phytochemistry letters. Volume 19(2017:Mar.)
• Page Start: 132
• Page End: 135
• Publication Date: 2017-03
• Subjects: Biphenyl derivatives -- Garcinia multiflora -- Cytotoxicity -- Anti-oxidant activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2016.12.021
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new biphenyl derivatives were isolated from Garcinia multiflora . All eight isolated compounds showed weak cytotoxic activity against five human tumor cell lines. Three biphenyl derivatives showed moderate anti-oxidant activity with IC50 values ranging from 7.78 to 8.78 μ M. Abstract: Three new biphenyl derivatives (1 –3 ), together with five known compounds, were isolated from the leaves and twigs of Garcinia multiflora . Their structures were determined by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. All eight isolates showed weak cytotoxicity on five human tumor cell lines. In addition, the three biphenyl derivatives showed moderate anti-oxidant activity with IC50 values ranging from 7.78 to 8.78 μ M.