Acridone alkaloids from Vepris verdoorniana (Excell & Mendonça) Mziray (Rutaceae). (March 2017)

• Record Type: Journal Article
• Authors: Atangana, Albert Fouda; Toze, Flavien Aristide Alfred; Langat, Moses K.; Happi, Emmanuel Ngeufa; Mbaze, Luc Leonard Meva'a; Mulholland, Dulcie A.; Waffo, Alain François Kamdem; Sewald, Norbert; Wansi, Jean Duplex
• Is Part Of: Phytochemistry letters. Volume 19(2017:Mar.)
• Page Start: 191
• Page End: 195
• Publication Date: 2017-03
• Subjects: Vepris verdoorniana -- Rutaceae -- acridone alkaloids -- antimicrobial and antioxidant activities; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.01.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: 17 Compounds were isolated by chromatography techniques from Vepris verdooniana . Two new alkaloids, verdoocridone A (1 ) and B (4 ) were characterized spectroscopic analyses. The 13 C NMR values of 1, 2, 3, 5-tetramethoxy- N -methylacridone (2 ) and 5-methoxyaborinine (3 ) are also reported. Some isolated compounds show moderate antimicrobial and antioxidant activities Abstract: Two new acridone alkaloids, verdoocridone A (1 ) and B (4 ), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana . The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI- and ESI–MS). The 13 C NMR values of 1, 2, 3, 5-tetramethoxy- N -methylacridone (2 ) and 5-methoxyaborinine (3 ) are also reported. The crude extracts and compounds (1 -6 ) were tested for their antimicrobial activity. The test delivered moderate activities for crude extracts and compounds1, 5 and6 against the bacterium Staphylococcus aureus and the fungi Mucor meihei and Candida albicans with MIC values between 115 and 180 μg/mL for extracts and between 21.3 and 29.4 μM for compounds, compared to gentamycin with 0.2 μM and nystatin with 5.2 μM against both fungi. The determination of the radical scanvenging activity using 1, 1-dephenyl-2-picrylhydrazyl (DPPH) assay gave moderate antioxidant values for all tested compounds, with IC50 between 0.29 and 0.41 μM, compared to the standard 3-t-butyl-4-hydroxyanisole (BHA) displaying 0.03 μM.