Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder. (April 2017)

• Record Type: Journal Article
• Authors: Baig, Fahd; Lawton, Michael A.; Rolinski, Michal; Ruffmann, Claudio; Klein, Johannes C.; Nithi, Kannan; Okai, David; Ben-Shlomo, Yoav; Hu, Michele T.M.
• Is Part Of: Parkinsonism & related disorders. Volume 37(2017)
• Page Start: 72
• Page End: 78
• Publication Date: 2017-04
• Subjects: Parkinson's disease -- Personality -- Addiction -- REM sleep behaviour disorder -- Smoking; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.01.017
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction. Methods: 941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory. Results: Patients with early PD were more neurotic (p < 0.001), less extraverted (p < 0.001) and less open than controls (p < 0.001). RBD subjects showed the same pattern of being more neurotic (p < 0.001), less extraverted (p = 0.03) and less open (p < 0.001). PD patients had smoked less (p = 0.02) and drunk less alcohol (p = 0.03) than controls, but caffeine beverage consumption was similar. Being more extraverted (p < 0.001), more open (p < 0.001), and less neurotic (p < 0.001) predicted higher alcohol use, while being more extravert (p = 0.007) and less agreeable (p < 0.001) was associated with smoking more. Conclusions: A similar pattern of personality changes is seen in PD and RBD compared to a control population. Personality characteristics were associated with addictive behaviours, suggestive of a common link, but the lower rates of addictive behaviours before and after the onset of motor symptoms in PD persisted after accounting for personality. Highlights: A similar pattern of personality change is seen in PD and RBD compared to controls. The similar pattern found suggests these personality changes occur before motor symptoms. Extraversion, linked with reward sensitivity, is associated with smoking and alcohol. Lower addictive behaviours before and after motor symptoms are not explained by personality alone. This suggests that inherent factors other than simple dopamine dysfunction drive these differences.