Association between dopaminergic dysfunction and anxiety in de novo Parkinson's disease. (April 2017)

• Record Type: Journal Article
• Authors: Picillo, Marina; Santangelo, Gabriella; Erro, Roberto; Cozzolino, Autilia; Amboni, Marianna; Vitale, Carmine; Barone, Paolo; Pellecchia, Maria Teresa
• Is Part Of: Parkinsonism & related disorders. Volume 37(2017)
• Page Start: 106
• Page End: 110
• Publication Date: 2017-04
• Subjects: Parkinson's disease -- Anxiety -- Dopaminergic -- Non motor symptoms -- Apathy -- Depression -- DAT -- SPECT; DAT dopamine transporter -- GDS-15 15-item Geriatric Depression Scale -- HC healthy controls -- MDS-UPDRS Movement Disorder Society-Unified Parkinson's Disease Rating Scale -- PD Parkinson' s disease -- PPMI Parkinson's Progression Markers initiative -- SBRs striatal binding ratios -- SD standard deviation -- SPECT single positron emission computerized tomography -- STAI State-Trait Anxiety Inventory; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.02.010
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Objectives: To explore the relationships between nigrostriatal dysfunction and neuropsychiatric symptoms (including anxiety, depression and apathy) in a large cohort of newly diagnosed, drug-naïve Parkinson disease (PD) patients compared to a cohort of healthy controls (HC). Methods: This is a cross-sectional analysis of the Parkinson's Progression Markers Initiative (PPMI) cohort at baseline, including 405 PD patients and 187 HC. Nigrostriatal degeneration was evaluated by means of SPECT DAT scan. Relationships between neuropsychiatric symptoms and DAT uptakes were analysed by means of stepwise multiple regression analysis. Results: In the PD group, lower DAT uptake in the right caudate was associated with higher STAI trait subscore (β = −2.939, 95%CI: −4.634 to −1.254, p = 0.001). Depression and apathy scores were not related with DAT uptakes. No associations were found in the HC group. Conclusions: Our cross-sectional analysis of the PPMI data shows that lower caudate DAT uptake is associated with higher level of anxiety. The data strengthens the relationship between dopaminergic dysfunction and neuropsychiatric symptoms in early PD. Highlights: This is a cross-sectional analysis of the PPMI cohort at baseline, including 405 PD and 187 HC. Lower caudate DAT uptake associated with higher level of anxiety in de novo PD patients. The data stress the link between dopaminergic dysfunction and neuropsychiatric symptoms in early PD.