Evolutionary control: Targeted change of allele frequencies in natural populations using externally directed evolution. (21st April 2017)

• Record Type: Journal Article
• Authors: Shafiey, Hassan; Gossmann, Toni I.; Waxman, David
• Is Part Of: Journal of theoretical biology. Volume 419(2017)
• Page Start: 362
• Page End: 374
• Publication Date: 2017-04-21
• Subjects: Evolutionary theory -- Random genetic drift -- Markov chain -- Diffusion approximation -- Genetic control; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2017.01.023
• Languages: English
• ISSNs: 0022-5193

Abstract

Abstract: Random processes in biology, in particular random genetic drift, often make it difficult to predict the fate of a particular mutation in a population. Using principles of theoretical population genetics, we present a form of biological control that ensures a focal allele's frequency, at a given locus, achieves a prescribed probability distribution at a given time. This control is in the form of an additional evolutionary force that acts on a population. We provide the mathematical framework that determines the additional force. Our analysis indicates that generally the additional force depends on the frequency of the focal allele, and it may also depend on the time. We argue that translating this additional force into an externally controlled process, which has the possibility of being implemented in a number of different ways corresponding to selection, migration, mutation, or a combination of these, may provide a flexible instrument for targeted change of traits of interest in natural populations. This framework may be applied, or used as an informed form of guidance, in a variety of different biological scenarios including: yield and pesticide optimisation in crop production, biofermentation, the local regulation of human-associated natural populations, such as parasitic animals, or bacterial communities in hospitals. Abstract : Highlights: We present a theoretical approach to biological control at the genetic level. We formulate external intervention into a population, as an additional evolutionary force. We derive the form of the force which results in a specified distribution of a focal allele. The additional force is generally frequency and time dependent. The force may apply to genetics, disease treatment and conservation.