Electrospun core/shell nanofibers as designed devices for efficient Artemisinin delivery. (April 2017)

• Record Type: Journal Article
• Authors: Bonadies, Irene; Maglione, Luca; Ambrogi, Veronica; Paccez, Juliano D.; Zerbini, Luiz F.; Rocha e Silva, Luiz F.; Picanço, Neila S.; Tadei, Wanderli P.; Grafova, Iryna; Grafov, Andriy; Carfagna, Cosimo
• Is Part Of: European polymer journal. Volume 89(2017)
• Page Start: 211
• Page End: 220
• Publication Date: 2017-04
• Subjects: Electrospun nanofibers -- Drug delivery -- Crystal suppressant -- Drug solubilizer -- Artemisinin; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2017.02.015
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: Novel core–shell nanofibers for drug delivery are developed through electrospinning. Artemisinin bioavailability is enhanced thanks to the hyperbranched polymer core. Nanofibers can be safely used into biological environment and deliver Artemisinin. Artemisinin loaded nanofibers show efficient anticancer and antimalarial activity. Abstract: Herein, engineered electrospun core/shell nanofibers containing different percents of Artemisinin (ART) were developed as new systems for drug administration in malaria and prostate cancer fields. In order to preserve drug bioavailability, a hyperbranched poly(butylene adipate) (HB), acting as crystal suppressant of ART, was employed as core material. Poly(vinylpirrolidone) (PVP) was selected as shell material being easy processable, self-standing and effective in facilitating ART release in aqueous medium. The investigation was carried out considering both the technological and biological aspects, by first assessing the release capability of nanofibers, and successively by evaluating the pharmacological activity of encapsulated ART against cancer cell proliferation and malarial parasites ( P. falciparum ) growth through in vitro tests. Inferred results confirmed the formation of nanofibers with an effective drug-loaded capability. Moreover, the different hydrophobic character of the HB and PVP enabled the triggering of the drug release and the control on its solubility in the aqueous medium.