Preparation, photoluminescence properties and application for in vivo tumor imaging of curcumin derivative-functionalized graphene oxide composite. (June 2017) - Xu, Guoyong
Abstract: Curcumin derivative-functionalized graphene oxide (CUDE-f-GO) composite was synthesized via direct polycondensation reaction in a binary phase system. The composite was characterized by FTIR, 1 H NMR, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), thermal gravimetric analysis (TGA) and atomic force microscopy (AFM). Digital camera and transmission electron microscopy (TEM) images showed that the composite had better dispersion in phosphate buffer solution (PBS) than graphene oxide (GO). The photophysical experiments revealed that the photoluminescence (PL) properties were significantly enhanced when curcumin derivative (CUDE) was covalently grafted on the surfaces of GO. The in vitro and in vivo bioimaging results showed that CUDE-f-GO composite was an ideal optical material for biological imaging because of its good photostability, low cytotoxicity, bright bioimaging and excellent tumor targeting ability. Graphical abstract: A new composite (CUDE-f-GO) was synthesized and characterized. The results showed that the composite was an ideal optical material for in vitro and in vivo bioimaging. Highlights: A novel composite (CUDE-f-GO) based on GO was synthesized. The photoluminescence of the composite were clearly enhanced. The derivative is a low toxicity at low-micromolar concentrations. The composite has excellent targeting capability to tested tumor.