The effect of peripheral neuropathy on lower limb muscle strength in diabetic individuals. (March 2017)

• Record Type: Journal Article
• Authors: Ferreira, Jean P.; Sartor, Cristina D.; Leal, Ângela M.O.; Sacco, Isabel C.N.; Sato, Tatiana O.; Ribeiro, Ivana L.; Soares, Alice S.; Cunha, Jonathan E.; Salvini, Tania F.
• Is Part Of: Clinical biomechanics. Volume 43(2017)
• Page Start: 67
• Page End: 73
• Publication Date: 2017-03
• Subjects: Muscle strength -- Polyneuropathy -- Diabetes -- Muscle function -- Low limbs -- Motor function; Biomechanics -- Periodicals; Osteopathic medicine -- Periodicals; Biomechanics -- Periodicals; Osteopathic Medicine -- Periodicals; 612.76
• DOI: 10.1016/j.clinbiomech.2017.02.003
• Languages: English
• ISSNs: 0268-0033

Abstract

Abstract: Background: Skeletal muscle strength is poorly described and understood in diabetic participants with diabetic peripheral neuropathy. This study aimed to investigate the extensor and flexor torque of the knee and ankle during concentric, eccentric, and isometric contractions in men with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. Methods: Three groups of adult men (n = 92), similar in age, body mass index, and testosterone levels, were analyzed: 33 non-diabetic controls, 31 with type 2 diabetes mellitus, and 28 with diabetic peripheral neuropathy. The peak torques in the concentric, eccentric, and isometric contractions were evaluated using an isokinetic dynamometer during knee and ankle flexion and extension. Findings: Individuals with diabetes and diabetic peripheral neuropathy presented similar low concentric and isometric knee and ankle torques that were also lower than the controls. However, the eccentric torque was similar among the groups, the contractions, and the joints. Interpretation: Regardless of the presence of peripheral neuropathy, differences in skeletal muscle function were found. The muscle involvement does not follow the same pattern of sensorial losses, since there are no distal-to-proximal impairments. Both knee and ankle were affected, but the effect sizes of the concentric and isometric torques were found to be greater in the participants' knees than in their ankles. The eccentric function did not reveal differences between the healthy control group and the two diabetic groups, raising questions about the involvement of the passive muscle components. Highlights: This is the first study analyzing knee and ankle torques at different contractions in type 2 diabetes with and without peripheral neuropathy. Regardless of the presence of peripheral neuropathy, there are differences in skeletal muscle strength in the type 2 diabetes. Knee and ankle torques were affected in diabetic subjects, but the knee concentric and isometric torques presented even larger effect sizes than the ankle. There were not differences at eccentric torque between both control and the two diabetic groups.