Inhibition of bone formation in rats by aluminum exposure via Wnt/β-catenin pathway. (June 2017)

• Record Type: Journal Article
• Authors: Sun, Xudong; Wang, Haoran; Huang, Wanyue; Yu, Hongyan; Shen, Tongtong; Song, Miao; Han, Yanfei; Li, Yanfei; Zhu, Yanzhu
• Is Part Of: Chemosphere. Volume 176(2017)
• Page Start: 1
• Page End: 7
• Publication Date: 2017-06
• Subjects: Aluminum trichloride -- Bone formation -- Wnt/β-catenin signaling pathway -- Rat; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2017.02.086
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: The previous research found that aluminum trichloride (AlCl3 ) inhibited rat osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in vitro. On that basis, the experiment in vivo was conducted in this study. Rats were orally exposed to 0 (control group) and 0.4 g/L AlCl3 (AlCl3 -treated group) for 30, 60, 90 or 120 days, respectively. We found that mRNA expressions of type I collagen and insulin-like growth factor-1, mRNA and protein expressions of Runx2 and survivin, ratio of p-GSK3β/GSK3β and protein expression of β-catenin were all decreased, whereas the mRNA and protein expressions Dkk1 and sFRP1 and the mRNA expressions and activity of Caspase-3 were increased in the AlCl3 -treated group compared with the control group with time prolonged. These results suggest that AlCl3 inhibits bone formation and induces bone impairment by inhibiting the Wnt/β-catenin signaling pathway in young growing rats. Highlights: Dynamic analysis of exposure to AlCl3 on rats bone formation. AlCl3 inactivated the Wnt/β-catenin signaling pathway in vivo . AlCl3 inhibited rats bone formation via inactivating Wnt/β-catenin signaling pathway.