Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens. Issue 8 (15th April 2017)

• Record Type: Journal Article
• Authors: Wang, Jianbin; Xie, Kehui; Duan, Hongquan; Wang, Yi; Ma, He; Fu, Hongzheng
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 8(2017)
• Page Start: 1815
• Page End: 1819
• Publication Date: 2017-04-15
• Subjects: Diterpenoid glycosides -- Siegesbeckia pubescens -- MB-MDA-231 breast cancer cells -- Chemokine epithelial growth factor; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.02.051
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Five new diterpenoid glycosides, siegesides A–E (1 –5 ), along with the known compound darutoside (6 ) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens . The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds1 and2 are epimers of6 . All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, and compound2 showed superior inhibitory activities in comparison with the positive control drug with IC50 value of 0.27 μM.