Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists. Issue 8 (15th April 2017)

• Record Type: Journal Article
• Authors: Zhang, Xuqing; Sui, Zhihua; Kauffman, Jack; Hou, Cuifen; Chen, Cailin; Du, Fuyong; Kirchner, Thomas; Liang, Yin; Johnson, Dana; Murray, William V.; Demarest, Keith
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 8(2017)
• Page Start: 1760
• Page End: 1764
• Publication Date: 2017-04-15
• Subjects: TGR5 -- Imidazole -- OGTT -- Gall bladder; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.02.069
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice. Abstract: A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice.