Kawasaki disease and immunisation: A systematic review. Issue 14 (27th March 2017)

• Record Type: Journal Article
• Authors: Phuong, Linny Kimly; Bonetto, Caterina; Buttery, Jim; Pernus, Yolanda Brauchli; Chandler, Rebecca; Felicetti, Patrizia; Goldenthal, Karen L.; Kucuku, Merita; Monaco, Giuseppe; Pahud, Barbara; Shulman, Stanford T.; Top, Karina A.; Trotta, Francesco; Ulloa-Gutierrez, Rolando; Varricchio, Frederick; de Ferranti, Sarah; Newburger, Jane W.; Dahdah, Nagib; Singh, Surjit; Bonhoeffer, Jan; Burgner, David
• Is Part Of: Vaccine. Volume 35:Issue 14(2017)
• Page Start: 1770
• Page End: 1779
• Publication Date: 2017-03-27
• Subjects: Kawasaki disease -- Adverse event -- Immunisation -- Guidelines -- Case definition -- Systematic review; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2016.09.033
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Background: Kawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation. Methods: We conducted a systematic literature review using various reference sources to review the available evidence published in the literature. Results: We identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging. Conclusions: Although a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.