Dual-hormone stress reactivity predicts downstream war-zone stress-evoked PTSD. (April 2017)

• Record Type: Journal Article
• Authors: Josephs, Robert A.; Cobb, Adam R.; Lancaster, Cynthia L.; Lee, Han-Joo; Telch, Michael J.
• Is Part Of: Psychoneuroendocrinology. Volume 78(2017)
• Page Start: 76
• Page End: 84
• Publication Date: 2017-04
• Subjects: Testosterone -- Cortisol -- Stress-reactivity -- PTSD -- Military -- War-zone assessment; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2017.01.013
• Languages: English
• ISSNs: 0306-4530

Abstract

Highlights: We tested the singular and interactive effects of cortisol (CR ) and testosterone (TR ) reactivity as moderators of PTSD emergence in theater. Blunted cortisol and testosterone stress reactivity at pre-deployment prospectively predicted PTSD symptom emergence in the war-zone. This hormonal reactivity profile appears to confer increased risk for PTSD by potentiating the pathogenic effects of war-zone stressors. Findings underscore the utility of assessing both HPA and HPG stress reactivity and may inform early detection of at risk soldiers for PTSD. Abstract: Background: The crucial role of the hypothalamic-pituitary-adrenal axis (HPA) in stress-related homeostasis suggests dysregulated HPA involvement in the pathogenesis of post-traumatic stress disorder (PTSD), yet most studies examining linkages between HPA axis measures and PTSD have yielded null findings. One untested explanation for this inconsistency is a failure to account for simultaneous adrenal and gonadal influence. Here we tested the singular and interactive effects of cortisol (CR ) and testosterone (TR ) reactivity as moderators of war-zone stress evoked PTSD emergence in the war-zone. Methods: U.S. soldiers (N = 120) scheduled for deployment to Iraq completed pre-deployment measures of CR and TR stress reactivity to a CO2 inhalation challenge. Once deployed, monthly assessments of exposure to traumatic war-zone stressors and PTSD symptoms were collected via a web-based assessment system. Results: Cortisol hypo-reactivity potentiated the pathogenic impact of war-zone stressors only in soldiers for whom the CO2 challenge did not elevate testosterone, suggesting that the dual hormone stress reactivity profile of blunted cortisol and testosterone may confer increased risk for PTSD emergence by potentiating the pathogenic effects of war-zone stressors. Conclusions: Findings underscore the utility of assessing both HPA and HPG stress reactivity when assessing PTSD vulnerability and may help inform efforts for enhanced soldier screening and inoculation to war-zone stressors.