Synthesis and structural characterization of a vanadium(V)-pyridylbenzimidazole complex: DNA binding and anticancer activity. (18th April 2017)

• Record Type: Journal Article
• Authors: Mal, Sunit Kumar; Chattopadhyay, Taraknath; Fathima, Aafreen; Purohit, Chandra Shekhar; Kiran, Manikantan Syamala; Nair, Balachandran Unni; Ghosh, Rajarshi
• Is Part Of: Polyhedron. Volume 126(2017)
• Page Start: 23
• Page End: 27
• Publication Date: 2017-04-18
• Subjects: Vanadium -- Pyridylbenzimidazole -- Crystal structure -- DNA binding -- Cytotoxicity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2017.01.008
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: One vanadium(V) compound [VO2 (L)(L − )] (1 ) [L = 2-(2-pyridyl)benzimidazole] (1 ) was synthesized and crystallographically characterized. It binds with DNA in intercalative mode with sufficiently high binding constant 2.76 × 10 5 M −1 .1 is active against human breast cancer, human lung cancer and human keratinocyte cancer cells. Abstract: Synthesis and structural characterization of a new pyridylimidazole based vanadyl compound [VO2 (L)(L − )] (1 ) [L = 2-(2-pyridyl)benzimidazole] (1 ) are reported. It crystallizes in P 1 ¯ space group. The molecular geometry of1 around vanadium(V) is found to be distorted octahedron.1 interacts with DNA in a intercalative fashion. Hypochromism of the absorption band of the complex with increasing concentration of DNA and the steady increase in DNA viscosity with increasing concentration of1 indicates intercalative mode of binding. The binding constant is calculated as 2.76 × 10 5 M −1 .1 also shows cytotoxicity against human breast cancer, human lung cancer and human keratinocyte cancer cell lines.