Two hands, one brain, and aging. (April 2017)

• Record Type: Journal Article
• Authors: Maes, Celine; Gooijers, Jolien; Orban de Xivry, Jean-Jacques; Swinnen, Stephan P.; Boisgontier, Matthieu P.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 75(2017)
• Page Start: 234
• Page End: 256
• Publication Date: 2017-04
• Subjects: BOLD blood-oxygen-level dependent -- CC corpus callosum -- CRUNCH compensation-related utilization of neural circuits -- DLPFC dorsolateral prefrontal cortex -- DMN default mode network -- dMRI diffusion magnetic resonance imaging -- DTI diffusion tensor imaging -- EEG electroencephalography -- FC functional connectivity -- fMRI functional magnetic resonance imaging -- GTNA graph theoretical network analyses -- HARDI high angular resolution diffusion imaging -- M1 primary motor cortex -- OA older adults -- PET positron emission tomography -- PMd dorsal premotor cortex -- S1 primary somatosensory cortex -- SII secondary somatosensory cortex -- SMA supplementary motor area -- SPL superior parietal lobule -- SUCAS age-related subcortico-cortical activation shift -- TMS transcranial magnetic stimulation -- VL Nc ventrolateral thalamic nucleus -- VPL Nc ventral posterolateral thalamic nucleus -- YA young adults; Bimanual coordination -- Brain -- Cognition -- Humans -- Motor control -- Motor learning; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2017.01.052
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Aging makes bimanual coordination performance more cognition-dependent. Hyper and hypo-activity in the aging brain may interact to determine performance. Higher resting-state connectivity is associated with lower performance in olders. Task-related connectivity increases with higher task demand irrespective of age. Abstract: Many activities of daily living require moving both hands in an organized manner in space and time. Therefore, understanding the impact of aging on bimanual coordination is essential for prolonging functional independence and well-being in older adults. Here we investigated the behavioral and neural determinants of bimanual coordination in aging. The studies surveyed in this review reveal that aging is associated with cortical hyper-activity (but also subcortical hypo-activity) during performance of bimanual tasks. In addition to changes in activation in local areas, the interaction between distributed brain areas also exhibits age-related effects, i.e., functional connectivity is increased in the resting brain as well as during task performance. The mechanisms and triggers underlying these functional activation and connectivity changes remain to be investigated. This requires further research investment into the detailed study of interactions between brain structure, function and connectivity. This will also provide the foundation for interventional research programs towards preservation of brain health and behavioral performance by maximizing neuroplasticity potential in older adults.