Bioactivity, cytocompatibility and thermal properties of experimental Bioglass-reinforced composites as potential root-canal filling materials. (May 2017)

• Record Type: Journal Article
• Authors: Alhashimi, Raghad Abdulrazzaq; Mannocci, Francesco; Sauro, Salvatore
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 69(2017)
• Page Start: 355
• Page End: 361
• Publication Date: 2017-05
• Subjects: Bioactivity -- Bioglass -- Cytotoxicity -- Polyethylene -- Root filling -- Thermal properties; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2017.01.022
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: To evaluate the bioactivity and the cytocompatibility of experimental Bioglass-reinforced polyethylene-based root-canal filling materials. The thermal properties of the experimental materials were also evaluated using differential scanning calorimetry, while their radiopacity was assessed using a grey-scale value (GSV) aluminium step wedge and a phosphor plate digital system. Bioglass 45S5 (BAG), polyethylene and Strontium oxide (SrO) were used to create tailored composite fibres. The filler distribution within the composites was assessed using SEM, while their bioactivity was evaluated through infrared spectroscopy (FTIR) after storage in simulated body fluid (SBF). The radiopacity of the composite fibres and their thermal properties were determined using differential scanning calorimetry (DSC). The cytocompatibility of the experimental composites used in this study was assessed using human osteoblasts and statistically analysed using the Pairwise t-test (p<0.05). Bioglass and SrO fillers were well distributed within the resin matrix and increased both the thermal properties and the radiopacity of the polyethylene matrix. The FTIR showed a clear formation of calcium-phosphates, while, MTT and AlamrBlue tests demonstrated no deleterious effects on the metabolic activity of the osteoblast-like cells. BAG-reinforced polyethylene composites may be suitable as obturation materials for endodontic treatment. Since their low melting temperature, such innovative composites may be easily removed in case of root canal retreatment. Moreover, their biocompatibility and bioactivity may benefit proliferation of human osteoblast cells at the periapical area of the root. Graphical abstract: Highlights: BAG/SrO-reinforced composites may be suitable materials for endodontic treatment. BAG/SrO-reinforced composites have good bioactivity and biocompatibility. Due to their low melting temperature, BAG/SrO composites may be easily removed in retreatment cases.