Computational assessment of hemodynamics-based diagnostic tools using a database of virtual subjects: Application to three case studies. Issue 16 (8th December 2016)

• Record Type: Journal Article
• Authors: Willemet, Marie; Vennin, Samuel; Alastruey, Jordi
• Is Part Of: Journal of biomechanics. Volume 49:Issue 16(2016)
• Page Start: 3908
• Page End: 3914
• Publication Date: 2016-12-08
• Subjects: Arterial hemodynamics -- 1D modelling -- Pulse wave velocity -- Central pressure -- Aortic flow -- Augmentation index; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2016.11.001
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: Many physiological indexes and algorithms based on pulse wave analysis have been suggested in order to better assess cardiovascular function. Because these tools are often computed from in-vivo hemodynamic measurements, their validation is time-consuming, challenging, and biased by measurement errors. Recently, a new methodology has been suggested to assess theoretically these computed tools: a database of virtual subjects generated using numerical 1D-0D modeling of arterial hemodynamics. The generated set of simulations encloses a wide selection of healthy cases that could be encountered in a clinical study. We applied this new methodology to three different case studies that demonstrate the potential of our new tool, and illustrated each of them with a clinically relevant example: (i) we assessed the accuracy of indexes estimating pulse wave velocity; (ii) we validated and refined an algorithm that computes central blood pressure; and (iii) we investigated theoretical mechanisms behind the augmentation index. Our database of virtual subjects is a new tool to assist the clinician: it provides insight into the physical mechanisms underlying the correlations observed in clinical practice.