Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+. Issue 2 (12th November 2014)

• Record Type: Journal Article
• Authors: Phillips, Daniel J.; Davies, Gemma-Louise; Gibson, Matthew I.
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 2(2015)
• Page Start: 270
• Page End: 275
• Publication Date: 2014-11-12
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c4tb01501k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Au nanoparticles modified with catechol-functionalised polymers provide a strong optical response which is highly specific to Fe 3+ ions at physiologically relevant concentrations. Abstract : Inspired by nature's exploitation of the 1, 2-dihydroxybenzene unit (or catechol) in mammalian and bacterial siderophores, we report the first example of a nanoparticle sensing system that utilises the strong catechol–Fe 3+ binding motif to trigger nanoparticle aggregation, promoting a powerful optical response. Gold nanoparticles are functionalised with RAFT polymerisation-prepared water-soluble poly( N -hydroxyethyl acrylamide) containing a catechol moiety at the α-chain-end. A strong red-to-purple colorimetric response occurs in the presence of Fe 3+ at serum concentrations (8–25 μM) in saline solution. Sodium chloride is critical in generating a strong optical output, as is the length of polymer used to coat the AuNPs. This behaviour is also demonstrated to be selective for Fe 3+ over a host of other biologically relevant ions.