Design of 2nd, 3rd and 4th Generations of Azido & 1, 2, 3‐Triazole Dendritic Esters and their Energetic and Biological Applications. Issue 10 (11th April 2017)

• Record Type: Journal Article
• Authors: Yamajala, Kanaka Durga B.; Banerjee, Shaibal
• Is Part Of: ChemistrySelect. Volume 2:Issue 10(2017)
• Page Start: 3152
• Page End: 3157
• Publication Date: 2017-04-11
• Subjects: Azido dendritic esters -- Bacterial studies -- Dendritic esters -- Triazole dendritc esters -- 4th generation dendritic esters; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201601935
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: 2 nd, 3 rd and 4 th generations of hyperbranched dendrimers of azido and 1, 2, 3‐triazoles have been synthesized from polyol hyperbranched dendrimers. Azides and 1, 2, 3‐triazoles are peripheral groups that scaffold these molecules. These molecules have been synthesized by three simple steps under mild conditions: tosylation, azidation and 1, 3‐dipolar addition (Click) reaction. Further, we have examined thermal, photophysical properties and have performed anti‐microbial studies. For dendritic esters having 16, 32 & 64 azido groups, sharp decomposition and high heat liberation was observed at temperature above 200 °C. Similarly, triazole dendritic esters possessed high enthalpy and high stability upto 300 o C. Some dendritic esters exhibited good anti‐bacterial properties against gram positive and negative bacteria. Abstract : 2 nd, 3 rd and 4 th generations of azido and 1, 2, 3‐triazole dendritic esters have been synthesized by simple synthetic route. The molecular structures were confirmed by spectroscopic methods and molecular weight determined by GPC. The thermal stability, heat flow, decomposition of compounds and UV‐visible properties of the molecules were evaluated. Anti‐bacterial studies of 1, 2, 3‐triazole dendritic esters were also explored on gram positive ( S.aureus and B.subtilis) and gram negative ( E.coli and F. Devorans) bacteria.