Facile one-pot synthesis of 4-substituted semicarbazides. Issue 2 (2nd December 2014)

• Record Type: Journal Article
• Authors: Bogolubsky, Andrey V.; Moroz, Yurii S.; Mykhailiuk, Pavel K.; Dmytriv, Yurii V.; Pipko, Sergey E.; Babichenko, Liudmyla N.; Konovets, Anzhelika I.; Tolmachev, Andrey
• Is Part Of: RSC advances. Volume 5:Issue 2(2015)
• Page Start: 1063
• Page End: 1069
• Publication Date: 2014-12-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c4ra12425a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A simple one-pot approach to 4-substituted semicarbazides allowed us to synthesize a 25 member library. Abstract : A diverse library of twenty-five 4-mono- and disubstituted semicarbazides was prepared in a one-pot two-step approach. The method includes formation of a carbamate from bis(2, 2, 2-trifluoroethyl)carbonate or 2, 2, 2-trifluoroethylchloroformate and a primary or secondary amine and subsequent interaction of the carbamate with hydrazine to result in a semicarbazide. The approach allowed to obtain 4-substituted semicarbazides on a large scale in good yield and high purity.