Targeting autophagy in cancer stem cells as an anticancer therapy. (1st May 2017)

• Record Type: Journal Article
• Authors: Lei, Yuanyuan; Zhang, Dan; Yu, Jin; Dong, Hui; Zhang, Jianwei; Yang, Shiming
• Is Part Of: Cancer letters. Volume 393(2017)
• Page Start: 33
• Page End: 39
• Publication Date: 2017-05-01
• Subjects: Anticancer therapy -- Autophagy -- Cancer stem cells -- Chemoresistance -- Stemness; 5-FU 5-fluorouracil -- ABC transporter -- ATP binding cassette transporters -- ABCC3 ATP Binding Cassette Subfamily C Member 3 -- ABCG2 ABC transporter gene2 -- ALDH aldehyde dehydrogenase -- AML acute myeloid leukemia -- ATG7 autophagy-related protein 7 -- ATP adenosine triphosphate -- BCC basal cell carcinoma -- cis-DDP cis-dichloro-diamine platinum -- CMA chaperone-mediated autophagy -- CRC colorectal cancer -- CSCs cancer stem cells -- DDR DNA damage response -- DDL4 Delta-Like Ligand 4 -- DNMT1 DNA methyltransferase 1 -- ECSCs esophageal cancer stem cells -- EMT epithelial–mesenchymal transition -- ESA epithelial-specific antigen -- FDA Food and Drug Administration -- GSCs glioblastoma stem cells -- HIFs hypoxia-inducible factors -- Jak2 Janus-activated kinase -- LC3B light chain 3B -- miRNA microRNA -- NOD/SCID mice non-obese diabetic mice with severe combined immunodeficiency disease -- NSCs neural stem cells -- OPN Osteopontin -- OS osteosarcoma -- PS-PDT Photosan-II (PS-II)-mediated photodynamic therapy -- ROS reactive oxygen species -- SP side population -- TNBC triple negative breast cancer -- TGF transforming growth factor -- UC urothelial carcinoma; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2017.02.012
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Cancer stem cells (CSCs), which comprise a small proportion of total cancer cells, have special capacities for self-renewal, differentiation and tumor formation. Currently, CSCs are regarded as the major cause of the failure in anticancer therapy, such as chemoresistance and/or radioresistance, tumor recurrence and metastasis. Autophagy, a process of cellular self-digestion and response to stress, has a role in tumor formation and progression, and it may play a dual role in CSCs-related resistance to anticancer therapy. Most researchers believe that autophagy contributes to stemness maintenance of CSCs and is responsible for the failure of anticancer therapy. Unexpectedly, several studies have also suggested that loss of stemness in CSCs could be mediated by autophagy. Here, we review the recent advances in CSCs and autophagy, especially analyze the complex relationship between them, and hope to apply this new knowledge to the strategies for anticancer therapy. Highlights: Autophagy may play a dual role in CSCs-related resistance to anticancer therapy. Autophagy could contribute to stemness maintenance of CSCs and is responsible for the failure of anticancer therapy. Loss of stemness in CSCs could also be mediated by autophagy.