Incidence, mortality and receptor status of breast cancer in African Caribbean women: Data from the cancer registry of Guadeloupe. (April 2017)

• Record Type: Journal Article
• Authors: Deloumeaux, J.; Gaumond, S.; Bhakkan, B.; Manip M'Ebobisse, Nsome; Lafrance, W.; Lancelot, Pierre; Vacque, D.; Negesse, Y.; Diedhiou, A.; Kadhel, P.
• Is Part Of: Cancer epidemiology. Volume 47(2017:Apr.)
• Page Start: 42
• Page End: 47
• Publication Date: 2017-04
• Subjects: Breast cancer -- Caribbean -- Incidence -- Hormone receptors -- Her2 -- Guadeloupe -- Survival; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2017.01.004
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Higher age-specific incidence rates of breast cancer for women between the age of 45 and 55 years old compared to European and US populations. Similar distribution of subtypes as those describe internationally in more than 90% of cases. Lower frequency of TNBC patients compared to other black populations. Good overall survival consistent with a good access to care for women with breast cancer. Abstract: Background: Geographical disparities in breast cancer incidence and outcomes are reported worldwide. Women of African descent show lower incidence, higher mortality rates and earlier age of onset. We analyzed data from the cancer registry of Guadeloupe for the period 2008–2013. Methods: We describe breast cancer characteristics by molecular subtype, as well as estimated observed and net survival. We used Cox proportional hazard models to determine associations between cancer subtypes and death rate, adjusted for variables of interest. Results: Overall, 1275 cases were recorded with a mean age at diagnosis of 57(±14) years. World standardized incidence and mortality were respectively 71.9/100, 000 and 14.1/100, 000 person-years. Age-specific incidence rates were comparable to European and US populations below the age of 45, and higher in Guadeloupean women aged between 45 and 55 years. Overall, 65.1% of patients were hormone receptor (HR)+ and 20.1% were HR-. Triple negative breast cancers (TNBC) accounted for 14% of all cases, and were more frequent in patients under 40 (21.6% vs. 13.4%, p = 0.02 ). Five-year net survival was 84.9% [81.4-88.6]. It was higher for HR+/Her2+ and HR+/Her2- subtypes, and lower for HR-/Her2+ and TNBC patients. Conclusion: We found high age-specific incidence rates of breast cancer in women aged 45 to 55 years, which warrants further investigation in our population. However, this population of mainly African descent had good overall survival rates, and data according to subtypes are consistent with those reported internationally. These results may suggest that poorer survival in other African descent populations may not be an inherent feature of the disease but may be amenable to improvement.